Zebularine 泽布拉林
CAS 3690-10-6 MFCD04973699
化学结构图
SMILES: O=c1ncccn1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
化学属性
| Mol. Formula | C9H12N2O5 |
|---|---|
| Mol. Weight | 228.20 |
别名和识别编码
| Chemical Name | Zebularine |
|---|---|
| CAS Number | 3690-10-6 |
| Synonym | 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one 2-Pyrimidone-1-β-D-riboside 1-?-D-Ribofuranosyl- 2-Pyrimidone-1-β-D-riboside Zebularine |
| MDL Number | MFCD04973699 |
| Chemical Name Translation | 泽布拉林 |
| Reaxys-RN | 751056 |
| PubChem Substance ID | 100016 |
| InChI | InChI=1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/m1/s1 |
| LabNetwork Molecule ID | LN01326575 |
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分类
- {SNA} A to C, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cytidine deaminase, DNA Methyltransferase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, E
- Inhibitors
- Carbohydrates & Derivatives
- Pharmaceuticals
- {SNA} A to C, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cytidine deaminase, DNA Methyltransferase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Nucleoside analog inhibitors, Z, 分子生物学, 生物活性小分子, 细胞生物学,
产品应用
- It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.
相关文献及参考
- Driscoll, J., et al.: J. Med. Chem., 34, 3280
- Cheng, J.C., et al., Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J. Natl. Cancer Inst. 95 , 399-409, (2003) 摘要
