4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮
CAS 327036-89-5 MFCD04973552
化学结构图
SMILES: CN1SC(=O)N(CC2C=CC=CC=2)C1=O
化学属性
| Mol. Formula | C10H10N2O2S |
|---|---|
| Mol. Weight | 222 |
| Melting Point | 61.0 to 65.0 deg-C |
别名和识别编码
| Chemical Name | 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |
|---|---|
| CAS Number | 327036-89-5 |
| Synonym | 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione GSK-3? Inhibitor I, TDZD-8 |
| MDL Number | MFCD04973552 |
| PubChem Substance ID | 354334062 |
| Chemical Name Translation | 4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮 |
| Reaxys-RN | 8763878 |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glycogen Synthase Kinase 3 (GSK3),
- {SNA} Bioactive Small Molecule Alphabetical Index,
- Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glycogen Synthase Kinase 3 (GSK3), Glycogen synthase kinase, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, T
- {SNA} Bioactive Small M
产品应用
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相关文献及参考
- Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)
- Martinez et al., First non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J. Med. Chem. 45 , 1292-1299, (2002)
- Chen, G. et al., Glycogen synthase kinase 3ß (GSK3ß) mediates 6-hydroxydopamine-induced neuronal.death.. FASEB J. 18 , 1162-1164., (2004) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P333+P313+P362+P364
- P342+P311
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
