L-Histidine L-组氨酸

CAS 71-00-1 MFCD00064315

化学结构图

71-00-1
SMILES: N[C@@H](Cc1c[nH]cn1)C(=O)O

化学属性

Mol. FormulaC6H9N3O2
Mol. Weight155.15
Density1.423
Melting Point282°C
TSCAYes
Stability对光敏感
Appearance powder 白色晶体或结晶性粉末。无臭。稍有苦味。约于277～288℃熔化并分解。其咪唑基易与金属离子形成络盐。溶于水(4.3g/100ml，25℃)，极难溶于乙醇，不溶于乙醚。 因溶解度极小等原因，常用者为其盐酸盐。
SolubilitySoluble in water (15 mg/ml at 20 °C).
Refractive index13 ° (C=11, 6mol/L HCl)
Boiling Point458.9°C at 760 mmHg
Flash Point231.3±25.9 °C

别名和识别编码

Chemical NameL-Histidine
Synonym L-Histidine {LY} L-Histidine {} {LY} L-Histidine {} {} {LY} L-Histidine {} {} {} {LY} L-Histidine {} {} {} {} {LY} L-Histidine {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Histidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00064315
CAS Number71-00-1
EC Number200-745-3
Beilstein Registry Number25,513
PubChem Substance ID6274
Merck Number4720
Chemical Name TranslationL-组氨酸
Reaxys-RN84088
InChIKeyHNDVDQJCIGZPNO-YFKPBYRVSA-N
LabNetwork Molecule IDLN00193432
InChIInChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
Canonical SMILESN[C@@H](CC1=CNC=N1)C(O)=O
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分类

  • {SNA} Amino Acid Derivatives, Amino acids, Chemical Biology, Chemical Synthesis, Functional Foods, Histidine, Nutrition Research, Peptide Chemistry
  • {SNA} Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Amino Acids, Amino acids, BioUltra, Biochemicals and Reagents, Cell Biology, Cichorium intybus (Chicory), Functional Foods, Ginkgo biloba, Humulus lupulus (Hops), Linum usitatissimum (Flax), Nutrition Research, Ocimum basilicum (Basil), Panax ginseng,
  • {SNA} All Alphabetically S
  • {SNA} Analytical Standards, Analytical/Chromatography,

产品应用

  • An essential amino acid, precursor to histamine and a component of carnosine.

相关文献及参考

  • [2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8.
  • [3]. Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144(10):1637-41.
  • Merck: 14,4720
  • Merck: 14,4720 Beilstein:25,513
  • Short: EINECS
  • Short: III/10a
  • Short: III/20a
  • [1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141.
  • [1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141.
  • [2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8.
  • [3]. Yoshikawa T, et al. Insufficie

安全信息

Signal word Warning
GHS Symbol
WGK Germany1
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSMS3070000
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {}

其他信息

  • Acros Organics:L-组氨酸 L-Histidine, 98%(71-00-1)
  • {
  • 所属类别一:生物化学品: 生化试剂: 氨基酸及其衍生物
  • Sigma Aldrich:71-00-1(sigmaaldrich)
  • 用途四:用作营养强化剂，是氨基酸输液、复合氨基酸制剂中的重要组成。可用于治疗胃溃疡。也用于生化研究。
  • 参考质量标准一:含量不少于99.0%，比旋光度[α] 20 D -40°--42°(0.5-2 mg/ml，水中)，氯化物(以Cl计)含量小于0.05%，硫酸盐(以SO 2- 4 计)含量小于0.03%，重金属(以Pb计)含量小于0.0015%；灼烧残渣、干燥失重、纸层析、盐酸溶解试验等项均合格。
  • 方法四:从
  • 方法四:从猪血、牛血中提取。猪血经喷雾干燥制得血粉，每100kg猪血约18kg血粉。L-组氨酸常用其盐酸盐（[7048-02-4]）。将含有L-组氨酸的洗脱液，浓缩至出现结晶，趁热
  • FEMA:
  • 用途一:氨基酸类药。氨基酸输液及综合氨基酸制剂的主要成分，用于治疗胃溃疡，贫血及心绞痛、主动脉炎、心功能
  • TCI Shanghai:L-组氨酸 L-Histidine,>;99.0%(LC)(T)(71-00-1)
  • L-组氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62014234 L-组氨酸 25g 40元
  • FEMA:3694
  • 比旋光度:12.4 ° (c=11,6N HCl)
  • 方法三:主要有两种制法。一是直接发酵法，以葡萄糖为碳源，以黄色短杆菌谷氨酸棒杆菌黏质赛氏杆菌等的诱导药物抗性株，通过直接发酵法制法。二是蛋白质水解法。下面详细介绍水解法。以猪(牛)血粉或猪毛或蹄甲为原料，经酸水解，然后分离精制而得。 水解 将猪血粉50kg和4倍量的6mol/L的HCl投入水解罐中，加热保温110-120℃，进行水解反应24h。 上柱稀释液的制备 将上步的水解液减压浓缩，再加蒸馏水，反复蒸馏去酸3-4次，直至馏出液无盐酸流出为止。浓缩液加蒸馏水稀释至500L，用浓氨水调pH至3.5-4，再加血粉投量20%的活性炭，加热90℃保温搅拌脱色6h趁热过滤，取滤液静置过夜析出沉淀，过滤取滤液，加蒸馏水稀释成2.5%(按血粉投量计)，并用浓HCl调pH至2.5，即得上柱稀释液。 上柱分离、水洗、洗脱 将上述稀释液上柱。柱子Ф300mm×2000mm， PVC质材，内装001×7(732)强酸性苯乙烯型阳离子交换树脂1730mm高，流速1L/min，直至流出液出现L组氨酸时，停止上柱。用水500L顺洗，流速1.5L/min。收集pH 7.0-10.0部分，收集完毕后，用水反冲树脂15min，再用2倍量1.5-2mol/L的HCl顺流动态再生，流速为5-13L/min，再生结束后，再用水洗至pH 4左右，待下次上柱。 精制 将组胺酸的洗脱液，减压除氨，浓缩至干，然后加人40L蒸馏水溶解，用6mol/L HCl调pH 3-3.2，加1kg活性炭，加热90℃保温搅拌脱色 30min，趁
  • MSDS 信息:His(71-00-
  • 用途二:用于生化研究，医药上用作治疗胃溃疡、贫血、过敏症等。
  • {C
  • 用途三:营养增补剂。 氨基酸输液及综合氨基酸制剂的极重要成分。医药上用于治疗胃溃疡、贫血、过敏症等。
  • 为天然的组氨酸。味甜。对空气敏感。在227℃时软化，287℃分解。水中溶解度为41.6 g/l (25°C)，极微溶于乙醇，不溶于乙醚、丙酮等有机溶剂，溶于无机酸。
  • 海关编码:29332990
  • 参考质量标准二:FCC，1992 含量(以干燥后) 98.5%～101.5% 重金属(以Pb计，GT-16-2) ≤10mg/kg 干燥失重(105℃，3h) ≤0.2% 灼烧残渣(GT-27) ≤0.2% 比旋光度[α] D 20 (干燥后试样11g/100ml，6mol/L,HCl) +11.5°～+13.5° [α] D 25 +12.0°～+14.0°

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Life Science Reagents for Cell Culture - Core Bioreagents
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. BioUltra - Amino Acids
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Amino Acid Library - Metabolic Libraries
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Functional Foods - Nutrition Research
  4. Amino acids - Functional Foods
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Allium sativum (Garlic) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Ginkgo biloba - Phytochemicals by Plant (Food/Spice/Herb)
  1. Analytical & Chromatography 分析化学与色谱
  2. Stable Isotopes 稳定同位素
  3. Alphabetical Listings for Stable Isotope Labeled Products
  4. G-H - Alphabetical Listings
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Histidine - Amino Acid Derivatives
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Histidine - Amino Acid Derivatives
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Nutraceuticals - Food & Beverage Standards
  6. Flavors and Fragrances - Nutraceuticals
  7. G-L - Flavors and Fragrances
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Certified Reference Materials (CRMs) - Analytical Standards
  4. Organic CRMs TraceCERT - Certified Reference Materials (CRMs)
  5. CRM for chromatography - Organic CRMs TraceCERT
  6. Organic CRMs Alphabetical - CRM for chromatography
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Albumins and Transport Proteins
  4. Albumin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Alkaloid
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteomics
  4. Recombinant Protein Expression and Analysis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Alkaloid
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Medical Research Areas
  2. Metabolism
  3. Mitochondrial Metabolism  (线粒体代谢)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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