2-Furoyl-LIGRLO-amide trifluoroacetate salt
CAS 729589-58-6 MFCD03821022
化学结构图
SMILES: CC1C=C(C)C2C(N)=C(SC=2N=1)C(=O)NCC1C=CC(Cl)=CC=1
化学属性
| Mol. Formula | C36H63N11O8· xC2HF3O2 |
|---|---|
| Mol. Weight | 777.95 (free base basis) |
别名和识别编码
| Chemical Name | 2-Furoyl-LIGRLO-amide trifluoroacetate salt |
|---|---|
| Synonym | 2-Furoyl-LIGRLO-amide trifluoroacetate salt 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt 2-Fly 2-f-LIGRLO-NH2 2-fAP 2fLI f-LIGRLO-NH2 |
| MDL Number | MFCD03821022 |
| PubChem Substance ID | 329799702 |
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分类
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics
- {SNA} Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87.
- [3]. Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol
- [1]. McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31.
- [1]. McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31.
- [2]. Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87.
- [3]. Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J I
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
