Splitomicin 斯普利特麻一辛
CAS 5690-03-9 MFCD03792600
化学结构图
SMILES: O=C1CCc2c(ccc3ccccc23)O1
化学属性
| Mol. Formula | C13H10O2 |
|---|---|
| Mol. Weight | 198.22 g/mol |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Splitomicin |
|---|---|
| Chemical Name Translation | 斯普利特麻一辛 |
| PubChem Substance ID | 5269 |
| InChI | InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2 |
| Formula | C13H10O2 |
| Synonym | Splitomicin |
| IUPAC Name | 1H-benzo[f]chromen-3(2H)-one |
| InChIKey | ISFPDBUKMJDAJH-UHFFFAOYSA-N |
| Canonical SMILES | O=C1CCC2=C3C=CC=CC3=CC=C2O1 |
| CAS Number | 5690-03-9 |
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产品应用
- Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release.
