Atorvastatin Calcium Salt Trihydrate 阿伐他汀钙
CAS 134523-03-8 MFCD03613598
化学结构图
SMILES: CC(C)C1=C(C(=C(C2C=CC(F)=CC=2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O[Ca]OC(=O)C[C@H](O)C[C@H](O)CCN1C(=C(C(=C1C(C)C)C(=O)NC1C=CC=CC=1)C1C=CC=CC=1)C1C=CC(F)=CC=1)C1C=CC=CC=1)C(=O)NC1C=CC=CC=1
化学属性
| Mol. Formula | C33H34FN2O5· 0.5 Ca · 1.5 H2O |
|---|---|
| Mol. Weight | 604.69 |
别名和识别编码
| Chemical Name | Atorvastatin Calcium Salt Trihydrate |
|---|---|
| Synonym | |
| PubChem Substance ID | 329823670 |
| Chemical Name Translation | 阿伐他汀钙 |
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分类
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Fluorination Ready Pharma-Developed Compounds, Lipids in Cell Signaling, Other, Pfizer Compounds, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
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- [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.
- [4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.
- [5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821.
- [1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;14
