Trans-4-((R)-1-Aminoethyl)-N-(Pyridin-4-Yl)Cyclohexanecarboxamide Dihydrochloride trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐

CAS 129830-38-2 MFCD03490488

化学结构图

129830-38-2
SMILES: CC(N)[C@@H]1CC[C@H](CC1)C(=O)NC1C=CN=CC=1 |&1:3,6|

化学属性

Mol. FormulaC14H21N3O·2HCl
Mol. Weight320

别名和识别编码

Chemical NameTrans-4-((R)-1-Aminoethyl)-N-(Pyridin-4-Yl)Cyclohexanecarboxamide Dihydrochloride
Synonym (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride Y-27632 dihydrochloride
MDL NumberN/A
PubChem Substance ID24277699
CAS Number129830-38-2
Chemical Name Translationtrans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, Protein Kinase Inhibitors, R to Z, Rho Kinase (ROCK), Rho-Associated protein kinase, Rho-Kinase, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Small Molecules for Stem Cell Biology, Y, 干细胞生物学, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物

相关文献及参考

  • [2]. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J (Engl). 2012 Sep;125(18):3332-5.
  • [3]. Inan S, et al. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. Br J Pharmacol. 2008 Sep;155(1):44-51.
  • [4]. Tada S, et al. A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. J Hepatol. 2001 Apr;34(4):529-36.
  • [5]. Maldonado M, et al. ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towardsmesendodermal lineage via epithelial-mesenchymal transition-like modulation. Stem Cell Res. 2016 Sep;17(2):222-227.
  • Chang, E., et al., MK2 SUMOylation Regulates Actin Filament Remodeling And Subsequent Migration In Endothelial Cells By Inhibiting MK2 Kinase And HSP27 Phosphorylation. Blood 117 , 2527-37, (2011) 摘要
  • Davies, S.P., et

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
Signal word Warning
Hazard statements
  • H302+H312+H332
Hazard Codes Xn
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. Y - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. R to Z - Enzyme Inhibitors by Enzyme
  7. Rho-Associated protein kinase - R to Z
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Rho Kinase (ROCK) - Serine/Threonine Kinase Inhibitors
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. ROCK  (Rho相关蛋白激酶)

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