2-(5-(4-Bromobenzylidene)-4-Oxo-2-Thioxothiazolidin-3-Yl)-3-Methylbutanoic Acid 2-(5-(4-溴苯基亚甲基)-4-氧代-2-硫代噻唑-3-基)-3-甲基丁酸
CAS 300817-68-9 MFCD03453544
化学结构图
SMILES: CC(C)C(C(O)=O)N1C(=S)S/C(=C/C2=CC=C(Br)C=C2)/C1=O
化学属性
| Mol. Formula | C15H14BrNS2O3 |
|---|---|
| Mol. Weight | 400.31 |
别名和识别编码
| Chemical Name | 2-(5-(4-Bromobenzylidene)-4-Oxo-2-Thioxothiazolidin-3-Yl)-3-Methylbutanoic Acid |
|---|---|
| Synonym | 5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid BH3I-1 |
| MDL Number | MFCD03453544 |
| Chemical Name Translation | 2-(5-(4-溴苯基亚甲基)-4-氧代-2-硫代噻唑-3-基)-3-甲基丁酸 |
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分类
- {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, B, Bioactive Small Molecule Alphabetical Index, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience
相关文献及参考
- [2]. Degterev A, et al. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol. 2001 Feb;3(2):173-82.
- [3]. Porter JR, et al. Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.
- [1]. Wang L, et al. Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
- [1]. Wang L, et al. Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
- [2]. Degterev A, et al. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol. 2001 Feb;3(2):173-82.
- [3]. Porter JR, et al. Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. Chem
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
