C75
CAS 218137-86-1 MFCD03426157
化学结构图
SMILES: CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
化学属性
| Mol. Formula | C14H22O4 |
|---|---|
| Mol. Weight | 254.32 |
别名和识别编码
| Chemical Name | C75 |
|---|---|
| Synonym | 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid |
| MDL Number | MFCD03426157 |
| PubChem Substance ID | 24892789 |
| CAS Number | 218137-86-1 |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cancer Metabolism, Cancer Research, Cell Biology, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,
- {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Fatty Acid Synthase (FAS) Inhibitors, Fatty acid synthase, Metabolites, Inhibitors and Activators of Fatty Acid Metabolism, 生化试剂, 生物活性小分子, 癌症代谢, 癌症发生过程中的脂肪酸代谢, 癌症研究, 细胞生物学, 酶、抑制剂和底物
- Bioactive Small Molecules,
相关文献及参考
- [2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.
- [3]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.
- [4]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.
- [5]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560.
- Kim, Y.M., et al., Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved In Cell Senescence. J. Thorac. Cardiovasc. Surg. 285 , 29069-77, (2010) 摘要
- Kumar, M.V.,
