Celastrol 雷公藤红素
CAS 34157-83-0 MFCD03424073
化学结构图
SMILES: CC1C2=CC=C3[C@@](C)(CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@@]43C)C(O)=O)C2=CC(=O)C=1O
化学属性
| Mol. Formula | C29H38O4 |
|---|---|
| Mol. Weight | 450.62 |
| Density | 1.2 |
| Solubility | Soluble in DMSO (>10 mg/ml), ethanol, DMF:PBS(pH 7.2)(1:10), and DMF. Insoluble in water. |
| Boiling Point | 645.7 |
| Melting Point | 203 |
别名和识别编码
| Chemical Name | Celastrol |
|---|---|
| CAS Number | 34157-83-0 |
| Synonym | 南蛇藤素 Celastrol (2R,4aS,6aS,6aR,14aS,14bR)-10-Hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid |
| MDL Number | MFCD03424073 |
| Chemical Name Translation | 雷公藤红素 |
| Reaxys-RN | 2194425 |
| PubChem Substance ID | 253660189 |
| Beilstein Registry Number | 2194425 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- Inhibitors
- Steroids
- {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM), 一氧化氮和细胞应激, 抗氧化剂和细胞保护剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞应激, 细胞生物学, 营养研究
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SA} Antioxidants and Cytoprotectants, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress
- {SNA} Antioxidants and Cytoprotectants, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress, Nutrition Research, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM)
产品应用
- 雷公藤红素是一种强力抗氧化，抗发炎剂。它是一种新型的HSP90的抑制剂（扰乱Hsp90/Cdc37复合物），抗癌（抗血管生成 - 抑制VEGFR的表达）;抗氧化剂（抑制脂质过氧化反应）和抗发炎活性（抑制iNOS及炎性细胞因子的生产）。
相关文献及参考
- [2]. Guan Y, et al. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway. Int J Mol Med. 2016 May;37(5):1229-38.
- Senger, D., et al.: Science, 219, 983 (1983),
- [1]. Yang H, et al. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66(9):4758-65
- [1]. Yang H, et al. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66(9):4758-65
- [2]. Guan Y, et al. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway. Int J Mol Med. 2016 May;37(5):1229-38.
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- R25 Toxic if swallowed 吞咽有毒
其他信息
- 存在于卫矛科植物雷公藤、南蛇藤等中的抗癌活性成分。该化合物结构载于2006年5月份Cancer Research杂志封面，并证实南蛇藤素通过抑制蛋白酶体活性进而诱发癌细胞凋亡，是有效的蛋白酶体抑制剂，其显著抑制了裸鼠身上前列腺癌的增生。因此，在癌症的预防和治疗方面，南蛇藤素是具有巨大开发潜力的天然蛋白酶体抑制剂。
