9-Bromo-7,12-Dihydrobenzo[2,3]Azepino[4,5-B]Indol-6(5H)-One 9-溴-7,12-二氢苯并[2,3]氮杂卓并[4,5-b]吲哚-6(5H)-酮
CAS 142273-20-9 MFCD02683595
化学结构图
SMILES: O=C1CC2=C(NC3C=CC(Br)=CC=32)C2C=CC=CC=2N1
化学属性
| Mol. Formula | C16H11BrN2O |
|---|---|
| Mol. Weight | 327.18 |
别名和识别编码
| Chemical Name | 9-Bromo-7,12-Dihydrobenzo[2,3]Azepino[4,5-B]Indol-6(5H)-One |
|---|---|
| CAS Number | 142273-20-9 |
| Synonym | 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one NSC 664704 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one 9-Bromopaullone Kenpaullone NSC 664704 |
| MDL Number | MFCD02683595 |
| PubChem Substance ID | 253661159 |
| Chemical Name Translation | 9-溴-7,12-二氢苯并[2,3]氮杂卓并[4,5-b]吲哚-6(5H)-酮 |
| Reaxys-RN | 5346108 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Apopt
- {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cyclin-Dependent Kinase (CDK), K, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学,
- Inhibitors
- {S
产品应用
- The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3? inhibitor (IC50=23nM).
相关文献及参考
- Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999),
- Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001),
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
