CAS N/A MFCD02179375

化学结构图

N/A
SMILES: CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1C=CC=CC=1

化学属性

Mol. FormulaC33H57F2N5O9
Mol. Weight705.83

别名和识别编码

Chemical Name
MDL NumberMFCD02179375
Synonym γ-Secretase inhibitor
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分类

  • {SA} γSecretase, Aldehydes, Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C13-C60, Carbonyl Compounds, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Neurodegenerative Disease Peptides, Neuropeptides, Organic Building Blocks, Other Alzheimer’s Peptides, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitor Specificity Index, Protease Inhibitors, R to Z, S, gamma Secretase
  • {SNA} γSecretase,

相关文献及参考

  • Wolfe, M.S., et al., Peptidomimetic probes and molecular modeling suggest that Alzheimer’s γ-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry 38 , 4720, (1999) 摘要
  • Wolfe, M.S., et al., A substrate-based difluoro ketone selectively inhibits Alzheimer’s γ-secretase activity. J. Med. Chem. 41 , 6, (1998) 摘要
  • Julian, J., et al., MUC1 Is A Substrate For Gamma-secretase. J. Cell. Mol. Med. 108 , 802-15, (2009) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. R to Z - Enzyme Inhibitors by Enzyme
  7. gamma Secretase - R to Z
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Protease Inhibitors - Enzyme Inhibitors
  6. Protease Inhibitor Specificity Index - Protease Inhibitors
  7. γSecretase - Protease Inhibitor Specificity Index

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