2-AMINO-N'-(4-HYDROXY-3-METHOXYBENZYLIDENE)-4-METHYL-1,3-THIAZOLE-5-CARBOHYDRAZIDE
CAS 292170-13-9 MFCD02086738
化学结构图
SMILES: CC1N=C(N)SC=1C(=O)N/N=C/C1=CC(OC)=C(O)C=C1
化学属性
| Mol. Formula | C13H14N4O3S |
|---|---|
| Mol. Weight | 306.34 |
别名和识别编码
| Chemical Name | OM137 |
|---|---|
| Synonym | 2-Amino-N′-(4-hydroxy-3-methoxybenzylidene)-4-methyl-1,3-thiazole-5-carbohydrazide 2-Amino-N'-(4-hydroxy-3-methoxybenzylidene)-4-methyl-1,3-thiazole-5-carbohydrazide 5-Thiazolecarboxylic acid, 2-amino-4-methyl-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide 5-Thiazolecarboxylic acid, 2-amino-4-methyl-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide |
| MDL Number | MFCD02086738 |
| CAS Number | 292170-13-9 |
| PubChem Substance ID | 329818924 |
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分类
- Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, O, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- DeMoe, J.H., et al., A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res. 69 , 1509-1516, (2009) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
