3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one 1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮
CAS 204005-46-9 MFCD01940922
化学结构图
SMILES: Cc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)[nH]1
化学属性
| Mol. Formula | C15H14N2O |
|---|---|
| Mol. Weight | 238 |
| Appearance | Yellow to orange solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
|---|---|
| Synonym | 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one SU 5416 SU5416; SU-5416; SU 5416; Sugen 5416; semoxind; Semaxanib |
| MDL Number | MFCD01940922 |
| PubChem Substance ID | 24278606 |
| CAS Number | 204005-46-9 |
| Chemical Name Translation | 1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮 |
| Formula | C15H14N2O |
| IUPAC Name | (Z)-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one |
| InChIKey | WUWDLXZGHZSWQZ-WQLSENKSSA-N |
| InChI | InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8- |
| Canonical SMILES | O=C1NC2=C(C=CC=C2)/C1=C/C3=C(C)C=C(C)N3 |
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分类
- {SNA} Angiogenesis, Angiogenesis Inhibitors, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, P to Q, Pfizer Compounds, Protein Kinase Inhibitors, Protein kinase, tyrosine, EGF receptor, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, S, Vascular Endothelial Growth Factor Receptor (VEGFR), 生化试剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- {SNA} Angiogenesis, Angiogenesis Inhibitors, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,
产品应用
- Semaxanib, also known as SU5416, is a quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.
相关文献及参考
- Takamoto, T.,et al, Flk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival. Kobe J. Med. Sci 47 , 181-191, (2001) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
