6-Iodo-2-Methyl-1-[2-(4-Morpholinyl)Ethyl]-1H-Indol-3-Yl](4-Methoxyphenyl)Methanone 碘代普拉朵林
CAS 164178-33-0 MFCD01861183
化学结构图
SMILES: COc1ccc(C(=O)c2c(C)n(CCN3CCOCC3)c3cc(I)ccc23)cc1
化学属性
| Mol. Formula | C23H25IN2O3 |
|---|---|
| Mol. Weight | 504 |
别名和识别编码
| Chemical Name | 6-Iodo-2-Methyl-1-[2-(4-Morpholinyl)Ethyl]-1H-Indol-3-Yl](4-Methoxyphenyl)Methanone |
|---|---|
| Synonym | 1-(2-(morpholin-4-yl)ethyl)-2-methyl-3-(4-methoxybenzoyl)-6-iodoindole 2-methyl-3-(4-methoxybenzoyl)-6-iodo-1-(2-morpholinoethyl)-1H-indole 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone AM 630 Iodopravadoline 6-iodopravadoline AM 630 AM-630 AM630 iodopravadoline methanone, (6-iodo-2-methyl-1-(2-(4-morpholinyl)ethyl)-1H-indol-3-yl)(4-methoxyphenyl)- |
| MDL Number | MFCD01861183 |
| PubChem Substance ID | 4302963 |
| Chemical Name Translation | 碘代普拉朵林 |
| InChI | InChI=1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3 |
| LabNetwork Molecule ID | LN00189385 |
| CAS Number | 164178-33-0 |
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分类
- {SNA} Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, Pharmacologicals
- {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Cannabinoids, Neurobiology, Neuroscience, Pharmacologicals, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Patil, Mayur., et al. Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology (2011), 61(4), 778-788.
- [3]. Geng, D. C., et al. Inhibition of titanium particle-induced inflammatory osteolysis through inactivation of cannabinoid receptor 2 by AM630. Journal of Biomedical Materials Research, Part A (2010), 95A(1), 321-326.
- [4]. Mukherjee, Sutapa., et al. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. European Journal of Pharmacology (2004), 505(1-3), 1-9.
- [5]. Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814.
- [1]. Garcia-Gutierrez, Maria S., et al. Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABAA receptors. British Journal of Pharmacology
安全信息
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- R50 Very toxic to aquatic organisms 对水生生物极毒
