(5R,5As,8Ar,9R)-9-Hydroxy-5-(3,4,5-Trimethoxyphenyl)-5,8,8A,9-Tetrahydrofuro[3',4':6,7]Naphtho[2,3-D][1,3]Dioxol-6(5Ah)-One (5R,5aS,8aR,9R)-9-羟基-5-(3,4,5-三甲氧基苯基)-5,8,8a,9-四氢呋喃[3',4':6,7]萘[2,3-d][1,3]二氧杂戊环基-6(5aH)-酮

CAS 477-47-4 MFCD01742647

化学结构图

477-47-4
SMILES: COc1cc(C2c3cc4c(cc3C(O)C3COC(=O)C23)OCO4)cc(OC)c1OC

化学属性

Mol. FormulaC22 H22 O8
Mol. Weight414.41
Density1.37

别名和识别编码

Chemical Name(5R,5As,8Ar,9R)-9-Hydroxy-5-(3,4,5-Trimethoxyphenyl)-5,8,8A,9-Tetrahydrofuro[3',4':6,7]Naphtho[2,3-D][1,3]Dioxol-6(5Ah)-One
Synonym (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one NSC 36407 PPP Picropodophyllin (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one NSC 36407 PPP Picropodophyllin AXL1717 IGF-1R 抑制剂;PPP NSC 36407 PPP Picropodophyllin Picropodophyllotoxin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD01742647
CAS Number477-47-4
Chemical Name Translation(5R,5aS,8aR,9R)-9-羟基-5-(3,4,5-三甲氧基苯基)-5,8,8a,9-四氢呋喃[3',4':6,7]萘[2,3-d][1,3]二氧杂戊环基-6(5aH)-酮
InChIKeyYJGVMLPVUAXIQN-HAEOHBJNSA-N
PubChem Substance ID72435
InChIInChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1
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分类

  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Insulin-Like Growth Factor Receptor (IGF1R and IGf2R), Kinase/Phosphatase Biology, P, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Insulin-Like Growth Factor Receptor (IGF1R and IGf2R), Kinase/Phosphatase Biology, P, Receptor Tyrosine Kinase Biology,
  • {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Insulin-Like Growth Factor Receptor (IGF1R and IGf2R), Kinase/Phosphatase Biology, P, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, 细胞生物学
  • {SNA} Bioactive S

产品应用

  • 苦鬼臼毒素是胰岛素样生长因子-I（IGF-I）受体激酶抑制剂。

相关文献及参考

  • Girnita, A., et al., The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells Clin. Cancer Res. 12 , 1383-1391, (2006) 摘要
  • Guha, M., et al., Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress J. Biol. Chem. 282 , 14536-14546, (2007) 摘要
  • Merck 14 ,7546
  • Merck: 14,7546

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes T
RTECSLV2510000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Storage condition -20°C -20℃ 贮存温度2-8℃
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R21 Harmful in contact with skin 与皮肤接触有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Receptor Tyrosine Kinase Inhibitors - Receptor Tyrosine Kinase Biology
  7. Insulin-Like Growth Factor Receptor (IGF1R and IGf2R) - Receptor Tyrosine Kinase Inhibitors

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