Narciclasine 水仙环素
CAS 29477-83-6 MFCD01729949
化学结构图
SMILES: OC1C2=C(C=C3OCOC=13)C1=C[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1NC2=O
化学属性
| Mol. Formula | C14H13NO7 |
|---|---|
| Mol. Weight | 307.26 |
别名和识别编码
| Chemical Name | Narciclasine |
|---|---|
| Synonym | (2S-(2-alpha,3-beta,4-beta,4a-beta))-3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-(1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one 3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one BRN 1087400 Lycoricidin-A Lycoricidinol NSC 266535 Lycoricidin-A Lycorcidinol Narciclasine Nacriclasine Lycoricidinol |
| MDL Number | MFCD01729949 |
| Beilstein Registry Number | 1087400 |
| CAS Number | 29477-83-6 |
| Chemical Name Translation | 水仙环素 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, N, Protein Kinase C (PKC), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, N, Protein Kinase C (PKC), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology
相关文献及参考
- [2]. Wahyuni DS, et al. The use of bio-guided fractionation to explore the use of leftover biomass in Dutch flower bulb production as allelochemicals against weeds. Molecules. 2013 Apr 17;18(4):4510-25.
- [1]. Lefranc F, et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol Cancer Ther. 2009 Jul;8(7):1739-50.
- [1]. Lefranc F, et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol Cancer Ther. 2009 Jul;8(7):1739-50.
- [2]. Wahyuni DS, et al. The use of bio-guided fractionation to explore the use of leftover biomass in Dutch flower bulb production as allelochemicals against weeds. Molecules. 2013 Apr 17;18(4):4510-25.
安全信息
GHS Symbol
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H340 May cause genetic defects 可能导致遗传性缺陷
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R46 May cause inheritable genetic damage 可能引起遗传基因损害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(1),126,1982
TYPE OF TEST : DNA damage TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 30 mg/L REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 32,67,1977
