Tofa 5-(十四氧基)呋喃-2-甲酸
CAS 54857-86-2 MFCD01726059
化学结构图
SMILES: CCCCCCCCCCCCCCOC1=CC=C(O1)C(O)=O
化学属性
| Mol. Formula | C19H32O4 |
|---|---|
| Mol. Weight | 324.45 |
| Melting Point | 112-115 °C |
别名和识别编码
| Chemical Name | Tofa |
|---|---|
| Synonym | 5-(Tetradecyloxy)-2-furancarboxylic acid 5-(Tetradecyloxy)-2-furoic acid 5-Tetradecyloxy-2-furonic acid MDL 14514 RMI 14514 |
| MDL Number | MFCD01726059 |
| CAS Number | 54857-86-2 |
| Beilstein Registry Number | 0539681 |
| PubChem Substance ID | 329826849 |
| Chemical Name Translation | 5-(十四氧基)呋喃-2-甲酸 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {SNA} A to C, Acetyl CoA-Carboxylase, Acetyl-CoA Carboxylase Inhibitors, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Metabolites, Inhibitors and Activators of Fatty Acid Metabolism, T, 生化试剂, 生物活性小分子,
- {SA} A to C, Acetyl CoA-Carboxylase,
相关文献及参考
- [2]. Li S, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo. Mol Med Rep. 2013 Aug;8(2):373-8.
- [3]. Guseva NV, et al. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol Ther. 2011 Jul 1;12(1):80-5.
- Landree, L.E., et al., C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. J. Biol. Chem. 279 , 3817-3827 , (2004)
- [1]. Wang C, et al. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun. 2009 Jul 31;385(3):302-6.
- [1]. Wang C, et al. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun. 2009 Jul 31;385(3):302-6.
- [2]. Li S, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo. Mol Med Rep. 2013 Au
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 1,19,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 1,19,1981
