CAS 122647-32-9 MFCD01715410-N-(4-(4-(Ethyl(Heptyl)Amino)-1-Hydroxybutyl)Phenyl)Methanesulfonamide Hemifumarate N-(4-(4-(乙基庚基胺)-1-羟基丁基)苯基)甲磺酰胺半富马酸盐 TAO{mole}

N-(4-(4-(Ethyl(Heptyl)Amino)-1-Hydroxybutyl)Phenyl)Methanesulfonamide Hemifumarate N-(4-(4-(乙基庚基胺)-1-羟基丁基)苯基)甲磺酰胺半富马酸盐

CAS 122647-32-9 MFCD01715410

化学结构图

SMILES: CS(=O)(=O)NC1C=CC(=CC=1)C(O)CCCN(CCCCCCC)CC.CS(=O)(=O)NC1C=CC(=CC=1)C(O)CCCN(CCCCCCC)CC.OC(=O)/C=C/C(O)=O

化学属性

Mol. Formula	C20H36N2O3S.1/2C4H4O4
Mol. Weight	442.62
TSCA	No

别名和识别编码

Chemical Name	N-(4-(4-(Ethyl(Heptyl)Amino)-1-Hydroxybutyl)Phenyl)Methanesulfonamide Hemifumarate
CAS Number	122647-32-9
Synonym	(±)-N-[4-(4-[Ethyl(n-heptyl)amino]-1-hydroxybutyl)phenyl]methanesulfonamide hemifumarate salt (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide hemifumarate salt Corvert (+-)-4'-(4-(Ethylheptylamino)-1-hydroxybutyl)methanesulfoanilide (+/-)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide Corvert Ibutilide hemifumarate salt
MDL Number	MFCD01715410
Merck Number	4883
Chemical Name Translation	N-(4-(4-(乙基庚基胺)-1-羟基丁基)苯基)甲磺酰胺半富马酸盐
PubChem Substance ID	253662069

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产品应用

A methanesulfonanilide antiarrhythmic agent; prologns myocardial action potential duration, predominantly by activation of slow inward sodium current. Antiarrhythmic (class III).

安全信息

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

WGK Germany1

Signal word Warning

Hazard Codes Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害

RTECSPB0475700

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 94200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 49,406,1994

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 49,406,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 54,157,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - body wall
   Reproductive - Specific Developmental Abnormalities - musculoske

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 54,157,1996