Eprazinon 盐酸依普拉酮
CAS 10402-53-6 MFCD01695215
化学结构图
SMILES: Cl.Cl.CC(CN1CCN(CC(OCC)C2C=CC=CC=2)CC1)C(=O)C1C=CC=CC=1
化学属性
| Mol. Formula | C24H32N2O2.2ClH |
|---|---|
| Mol. Weight | 453.50 |
别名和识别编码
| Chemical Name | Eprazinon |
|---|---|
| EC Number | 233-872-8 |
| Synonym | 1-(2-Benzoylpropyl)-2-(2-ethoxy-2-phenylethyl)piperazine dihydrochloride Eprazinone hydrochloride Eprazinone dihydrochloride 1-(2-Benzoylpropyl)-4-(2-ethoxy-2-phenylethyl)piperazine dihydrochloride; 3-[4-(2-Ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one dihydrochloride 2-(4-(beta-Ethoxyphenethyl)-1-piperazinylmethyl)propiophenone Eftapan 746 CE |
| CAS Number | 10402-53-6 |
| Wiswesser Line Notation | T6N DNTJ A1Y1&VR& D1YR&O2 &GH 2 |
| Chemical Name Translation | 盐酸依普拉酮 |
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相关文献及参考
- [2]. Yvonne Krautscheid, et al. Pharmacophore Modeling, Virtual Screening, and in Vitro Testing Reveal Haloperidol, Eprazinone, and Fenbutrazate as Neurokinin Receptors Ligands. J Chem Inf Model. 2014 Jun 23;54(6):1747-57.
- [1]. R S Thrall, et al. Eprazinone Alters Lung Lavage Lipid Levels and Transtracheal Ion Transport. Exp Lung Res. May-Jun 1992;18(3):409-20.
- [1]. R S Thrall, et al. Eprazinone Alters Lung Lavage Lipid Levels and Transtracheal Ion Transport. Exp Lung Res. May-Jun 1992;18(3):409-20.
- [2]. Yvonne Krautscheid, et al. Pharmacophore Modeling, Virtual Screening, and in Vitro Testing Reveal Haloperidol, Eprazinone, and Fenbutrazate as Neurokinin Receptors Ligands. J Chem Inf Model. 2014 Jun 23;54(6):1747-57.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 286 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,232,1979
TYPE OF TEST : LD50 - Lethal do
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 191 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,232,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCIPDV Beijing Yixueyuan Xuebao. Journal of Peking Medical College. (Beijing Yixueyuan, Beijiaohaidianqu, Beijing, Peop. Rep. China) 19??-V.17(3), 1985. Volume(issue)/page/year: 13(2),98,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 763 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year:
