4'-Hydroxy diclofenac 4′-羟基双氯芬酸

CAS 64118-84-9 MFCD01671980

化学结构图

64118-84-9
SMILES: OC1C=C(Cl)C(NC2=CC=CC=C2CC(O)=O)=C(Cl)C=1

化学属性

Mol. FormulaC14H11Cl2NO3
Mol. Weight312.16
TSCANo

别名和识别编码

Chemical Name4'-Hydroxy diclofenac
CAS Number64118-84-9
Synonym 2-((2,6-二氯-4-羟基苯基)氨基)苯乙酸 4′-羟基双氯灭痛 4′-羟基双氯芬酸 (o-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid [2-(2,6-Dichloro-4-hydroxy-phenylamino)phenyl]acetic acid Benzeneacetic acid, 2-((2,6-dichloro-4-hydroxyphenyl)amino)- 2-[(2,6-Dichloro-4-hydroxyphenyl)amino]benzeneacetic Acid 4'-Hydroxydiclofenac
MDL NumberMFCD01671980
PubChem Substance ID24895589
Beilstein Registry Number4198042
Chemical Name Translation4′-羟基双氯芬酸
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, H, HU - HZ, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors
  • Pharmaceuticals
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Drugs, Additional Standards, Analytical Standards, Chromatography, Diclofenac Metabolites, Pharmaceutical Standards, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography,

产品应用

  • A metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.

相关文献及参考

  • [2]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43(3):309-16.
  • Bort, R., et al.: J. Pharmacol. Exp. Ther., 288, 65 (1998),
  • Kretz-Rommel, A., et al.: Toxicol. Appl. Pharmacol., 120, 155 (1993),
  • Petronilli, V., et al.: J. Biol. Chem., 269, 16638 (1994),
  • [1]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8.
  • [1]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8.
  • [2]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjug

安全信息

Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H318 Causes serious eye damage 严重伤害眼睛
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSAG6542800
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
Hazard Codes T,N
Risk Statements
  • R50/53
  • R25 Toxic if swallowed 吞咽有毒
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
Packing GroupIII
UN Number UN2811 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SJRHAT Scandinavian Journal of Rheumatology.  (Almqvist & Wiksell, POB
   45150, S-10430 Stockholm, Sweden)  V.1-    1972-  Volume(issue)/page/year:
   (Suppl 22),5,1978

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. H - Alphabetic
  5. HU - HZ - H
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Multi-Drug Resistance and Drug Metabolism - Cell Signaling and Neuroscience
  5. Drug and Xenobiotic Metabolism - Multi-Drug Resistance and Drug Metabolism
  6. Substrates, Inducers, Inhibitors - Drug and Xenobiotic Metabolism
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. API Metabolites - Pharmaceutical Standards
  6. All alphabetical sorted - Active Pharmaceutical Ingredients (API) and its Metabolites
  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

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