Benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis-
CAS 73819-26-8 MFCD01656960
化学结构图
SMILES: NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=N
化学属性
| Mol. Formula | C18H16N4O |
|---|---|
| Mol. Weight | 304.38 |
别名和识别编码
| Chemical Name | Benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis- |
|---|---|
| CAS Number | 73819-26-8 |
| Synonym | NSC 305831 2,5-Bis(4-guanylphenyl)furan 4,4'-(2,5-Furandiyl)bis(benzenecarboximidamide) 2,5-Bis(4-amidinophenyl)furan 4,4'-(2,5-Furandiyl)bisbenzenecarboximidamide |
| Beilstein Registry Number | 1435532 |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Furamidine is a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiprolifer
相关文献及参考
- [2]. Antony S, et al. Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1. Nucleic Acids Res. 2007;35(13):4474-84.
- [3]. Keil A, et al. The Topoisomerase I Inhibitor Irinotecan and the Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Furamidine Synergistically Suppress Murine Lupus Nephritis. Arthritis Rheumatol. 2015 Jul;67(7):1858-67.
- Lansiaux, A. et al.: Cancer Res., 62, 7219 (2002); Steck E.A. et al.: Exp. Parasitol., 52, 404 (1981); Balzarini, J. et al.: Incest. New Drugs, 1, 103 (1983);
- [1]. Yan L, et al. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J Med Chem. 2014 Mar 27;57(6):2611-22.
- [1]. Yan L, et al. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J Med Chem. 2014 Mar 27;57(6):2611-22.
- [2]. Antony S, et al. No
安全信息
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 91 mg/L REFERENCE : INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 1,103,1983
