α-Chymotrypsin from bovine pancreas 糜蛋白酶
CAS 9004-07-3 MFCD00130481
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {SNA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Cell Dissociation, Cell Dissociation and Cell Lysis, Chymotrypsin, al
- {SNA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Chymotrypsin, alpha-, Enzymatic and Chemical Protein Cleavage, Enzyme Class Index, Proteases for Cleavage of Proteins, Proteolytic Enzymes, Proteolytic Enzymes and Substrates, Selective Proteolytic Enzymes, 分子生物学, 生化试剂, 蛋白质组学, 质谱, 酶、抑制剂和底物
- {SNA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Biochemicals and Reagents, Enzyme Class Index, Enzy
产品应用
- 一种丝氨酸蛋白酶,水解肽键的羧基端带有芳香或长疏水链(Tyr, Trp, Phe, Met)的肽键。
- 备注:用于没有外源胰蛋白酶活性存在条件下的蛋白质水解。
相关文献及参考
- D'Arienzo, R., et al., Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity. Cytokine 48 , 254-9, (2009) 摘要
- D'Arienzo, R., et al., Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity. Immunol. Lett. 119 , 78-83, (2008) 摘要
- Ehren, J., et al., A food-grade enzyme preparation with modest gluten detoxification properties. PLoS Biol. 4 , e6313, (2009) 摘要
- Merck 14 ,2260
- Matthew, S., et al., Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Planta Med. 75 , 528-33, (2009) 摘要
- Cleemann, F., and Karuso, P., Fluorescence anisotropy assay for the traceless kinetic analysis of protein digestion. Anal. Biochem. 80 , 4170-4, (2008) 摘要
- Ziemert, N., et al., Exploiting The Natural Diversity Of Microviridin Gene Clusters For Discovery Of Novel Tricyclic Depsipeptides. Appl. Environ. Microbiol. 76 , 3568-74, (2010) 摘要
- Merck: 14,2260
- Karuso, P., et al., Real-time fluorescence monitoring of tryptic digestion in proteomics. J. Proteome Res. 7 , 361-6, (2008) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
- P302+P350
- P302+P352+P332+P313+P362+P364
- P304+P340
- P304+P340+P312
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P337+P313
- P342+P311
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S22 Do not breathe dust 不要吸入粉尘;
- S24 Avoid contact with skin 避免皮肤接触;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R42 May cause sensitisation by inhalation 吸入会产生过敏反应
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 116 mg/kg TOXIC EFFECTS : Details of toxic effects not r
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 104 mg/kg TOXIC EFFECTS : Details of toxic effects not reported oth
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 185 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,202,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPO
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 50000 units/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Cardiac - other changes Blood - hemorrhage REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 106,164,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 24000 units/kg TOXIC EFFECTS : Gastrointestinal - other changes Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : AIPTAK Archives Internationales de Pharm
其他信息
- 糜蛋白酶又称胰凝乳蛋白酶,是一种蛋白水解酶,它能优先水解L-酪氨酸和L-苯丙氨酸的羧基所形成的肽键。酶作用最优化的PH值为8.0~9.0。糜蛋白酶活性能被重金属和天然胰蛋白酶抑制剂不同程度地抑制。白色或类白色结晶状。分子量约25 kDa。 Enzyme Commission (EC) Number: 3.4.21.1
- Chymotrypsin preferentially catalyzes the hydrolysis of peptide bonds involving L-isomers of tyrosine, phenylalanine and tryptophan. It also readily acts upon amides and esters of susceptible amino acids. Chymotrypsin catalyzes the hydrolysis of bonds of leucyl, methionyl, asparaginyl and glutamyl residues.