Clasto-Lactacystin .beta.-lactone
CAS 154226-60-5 MFCD01076526
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Application Index, Bioactive Small Molecule Alphabetical Index, CI-CZ, Calpain and Proteasome Inhibitors, Cell Signaling Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Inhibitors, Intracellular Protein Degradation, Nitric Oxide and Cell Stress, P to Q, Protease Inhibitor Specificity Index, Protease Inhibitors, Proteasome inhibitor, Proteasome, Calpain and Lysosomal Proteases, Proteasomes, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- {SNA} Application Index, Bioactive Small Molecules, Biochemicals and Reagents, CI-CY,
- {SNA} Application Index,
产品应用
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相关文献及参考
- Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997),
- Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997),
- Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998),
- Craiu, A., et al., Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J. Biol. Chem. 272 , 13437-13445, (1997) 摘要
- Dick, L.R., et al., Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells. J. Biol. Chem. 272 , 182-188, (1997) 摘要
- Dick, L.R., et al., Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin β-lactone. J. Biol. Chem. 271 , 7273-7276, (1996) 摘要
- Fenteany, G., et al., Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268 , 726-731, (1995) 摘要
- Capo-chichi, C.D., et al., Loss Of GATA6 Leads To Nuclear Deformation And Aneuploidy In Ovarian Cancer. Mol. Cell. Biol. 29 , 4766-77, (2009) 摘要
安全信息
GHS Symbol
- P301+P310
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H301 Toxic if swallowed 吞食有毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- R25 Toxic if swallowed 吞咽有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性