Cephalomannine, 98%, from Taxus chinensis 三尖杉宁碱
CAS 71610-00-9 MFCD01075131
化学结构图
SMILES: CC1(C)C2[C@@H](OC(C)=O)C(=O)[C@@]3(C)[C@H]([C@H](OC(=O)C4C=CC=CC=4)[C@]1(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)/C(/C)=C/C)C1C=CC=CC=1)C=2C)[C@@]1(CO[C@@H]1C[C@@H]3O)OC(C)=O
化学属性
| Mol. Formula | C45H53NO14 |
|---|---|
| Mol. Weight | 832 |
| Melting Point | 260-262 |
别名和识别编码
| Chemical Name | Cephalomannine, 98%, from Taxus chinensis |
|---|---|
| CAS Number | 71610-00-9 |
| Synonym | ######## Cephalomannine NSC 318735 |
| MDL Number | MFCD01075131 |
| PubChem Substance ID | 24724441 |
| Chemical Name Translation | 三尖杉宁碱 |
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分类
- {SNA} Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecule Alphabetical Index,
- Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Chemical Structure Class, D to K, DNA polymerase - alpha, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Interferes with DNA Synthesis, Mechanism of Action, Penicillins and Cephalosporins (beta-Lactams)
- {SNA} Antibiotics A to Z, Antibiotics
产品应用
- Antitumor, antiproliferative.
相关文献及参考
- [2]. Jianhua Li, et al. Microbial transformation of cephalomannine by Luteibacter sp. J Nat Prod. 2007 Dec;70(12):1846-9.
- Stenken, J., et al.: J. Pharm. Sci., 86, 958
- [1]. Feng Gao, et al. Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel analogs from cephalomannine.Fitoterapia. 2013 Oct;90:79-84.
- [1]. Feng Gao, et al. Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel analogs from cephalomannine.Fitoterapia. 2013 Oct;90:79-84.
- [2]. Jianhua Li, et al. Microbial transformation of cephalomannine by Luteibacter sp. J Nat Prod. 2007 Dec;70(12):1846-9.
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S39 Wear eye/face protection 戴眼睛/面孔保护装置；
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
