Rosuvastatin Calcium 瑞舒伐他汀钙
CAS 147098-20-2 MFCD00953841
化学结构图
SMILES: [Ca+2].CS(=O)(=O)N(C)C1=NC(C(C)C)=C(/C=C/[C@@H](O)C[C@@H](O)CC([O-])=O)C(=N1)C1C=CC(F)=CC=1.CS(=O)(=O)N(C)C1=NC(C(C)C)=C(/C=C/[C@@H](O)C[C@@H](O)CC([O-])=O)C(=N1)C1C=CC(F)=CC=1 |&1:16,19,49,52|
化学属性
| Mol. Formula | C22H27FN3O6S?1/2Ca |
|---|---|
| Mol. Weight | 500.57 |
别名和识别编码
| Chemical Name | Rosuvastatin Calcium |
|---|---|
| CAS Number | 147098-20-2 |
| Synonym | (3R,5S,6E)- |
| Chemical Name Translation | 瑞舒伐他汀钙 |
| LabNetwork Molecule ID | LN01327270 |
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分类
- Aromatics
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- A selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
相关文献及参考
- [2]. Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.
- [3]. Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78.
- [4]. Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr 1;16(4):1477-1488.
- Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006),
- Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005),
- Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997),
- [1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrol
- [1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.
