4-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol 4-(4-氯苯基)-1-(1H-吲哚-3-基甲基)-4-哌啶醇
CAS 81226-60-0 MFCD00953632
化学结构图
SMILES: OC1(CCN(CC2=CNC3C=CC=CC2=3)CC1)C1C=CC(Cl)=CC=1
化学属性
| Mol. Formula | C20H21ClN2O |
|---|---|
| Mol. Weight | 340.85 |
别名和识别编码
| Chemical Name | 4-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol |
|---|---|
| Synonym | (±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole L-741,626 |
| MDL Number | MFCD00953632 |
| PubChem Substance ID | 24278529 |
| CAS Number | 81226-60-0 |
| Chemical Name Translation | 4-(4-氯苯基)-1-(1H-吲哚-3-基甲基)-4-哌啶醇 |
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分类
- {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, L, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
- {SNA} Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators,
相关文献及参考
- [2]. Grundt P, et al. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett. 2007 Feb 1;17(3):745-9.
- [3]. Koffarnus MN, et al. The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats. Psychopharmacology (Berl). 2009 Apr;203(2):317-27.
- [4]. Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.
- [1]. Lewitus GM, et al. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. 2016 May 4;90(3):483-91.
- [1]. Lewitus GM, et al. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. 2016 May 4;90(3):483-91.
- [2]. Grundt P, et al. Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med
