Tipranavir N-(3-((R)-1-((R)-4-羟基-2-氧代-6-苯乙基-6-丙基-5,6-二氢-2H-吡喃-3-基)丙基)苯基)-5-(三氟甲基)吡啶-2-磺酰胺
CAS 174484-41-4 MFCD00949098
化学结构图
SMILES: CC[C@@H](C1=C(O)C[C@@](CCC)(CCC2C=CC=CC=2)OC1=O)C1=CC(=CC=C1)NS(=O)(=O)C1C=CC(=CN=1)C(F)(F)F
化学属性
| Mol. Formula | C31H33F3N2O5S |
|---|---|
| Mol. Weight | 602.66 |
别名和识别编码
| Chemical Name | Tipranavir |
|---|---|
| CAS Number | 174484-41-4 |
| Synonym | N-[3-[(1R)-1-[(6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide |
| Chemical Name Translation | N-(3-((R)-1-((R)-4-羟基-2-氧代-6-苯乙基-6-丙基-5,6-二氢-2H-吡喃-3-基)丙基)苯基)-5-(三氟甲基)吡啶-2-磺酰胺 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Nonpeptidic HIV protease inhibitor (NPPI). Antiviral.
相关文献及参考
- [2]. Li F, et al. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May;38(5):871-8.
- [3]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
- Boffito, M., et al.: J. Clin. Pharmacol., 46, 130 (2006),
- McGregor, T.R., et al.: HIV Clin. Trials, 5, 371 (2004),
- Poppe, S.M., et al.: Antimicrob. Agents Chemother., 41, 1058 (1997),
- [1]. Aoki M, et al. Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol. 2012 Dec;86(24):13384-96.
- [1]. Aoki M, et al. Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol. 2012 Dec;86(24):13384-96.
- {
