N-(3-Chloro-4-(10,11-Dihydro-5H-Benzo[e]Pyrrolo[1,2-a][1,4]Diazepine-10-Carbonyl)Phenyl)-5-Fluoro-2-Methylbenzamide N-(3-氯-4-(10,11-二氢-5H-苯并[e]吡咯[1,2-a][1,4]二氮杂-10-羰基)苯基)-5-氟-2-甲基苯甲酰胺
CAS 168079-32-1 MFCD00937905
化学结构图
SMILES: CC1=CC=C(F)C=C1C(=O)NC1C=C(Cl)C(=CC=1)C(=O)N1CC2=CC=CN2CC2=CC=CC=C12
化学属性
| Mol. Formula | C27H21ClFN3O2 |
|---|---|
| Mol. Weight | 474 |
别名和识别编码
| Chemical Name | N-(3-Chloro-4-(10,11-Dihydro-5H-Benzo[e]Pyrrolo[1,2-a][1,4]Diazepine-10-Carbonyl)Phenyl)-5-Fluoro-2-Methylbenzamide |
|---|---|
| CAS Number | 168079-32-1 |
| Synonym | N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methyl-benzamide VPA 985 WAY-VPA 985 |
| Chemical Name Translation | N-(3-氯-4-(10,11-二氢-5H-苯并[e]吡咯[1,2-a][1,4]二氮杂-10-羰基)苯基)-5-氟-2-甲基苯甲酰胺 |
| MDL Number |
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资金保障
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Drug used in the treatment and prevention of cardiovascular diseases.
相关文献及参考
- [2]. Ghali JK, et al. Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia. IDrugs. 2010 Nov;13(11):782-92.
- Ghali, J., et al.: Cardiol., 111, 147 (2008),
- Lo, R., et al.: Curr. Clin. Pharmacol., 3, 156 (2008),
- [1]. Albright JD, et al. 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors. J Med Chem. 1998 Jul 2;41(14):2442-4.
- [1]. Albright JD, et al. 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors. J Med Chem. 1998 Jul 2;41(14):2442-4.
- [2]. Ghali JK, et al. Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia. IDrugs. 2010 Nov;13(11):
