Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)- 乙酸阿比特龙酯
CAS 154229-18-2 MFCD00934213
化学结构图
SMILES: CC(=O)O[C@@H]1CC2=CC[C@H]3[C@@H]4CC=C(C5C=NC=CC=5)[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1
化学属性
| Mol. Formula | C26H33NO2 |
|---|---|
| Mol. Weight | 391.56 |
| Solubility | DMSO <1 mg/mL Water <1 mg/mL Ethanol 28 mg/mL |
| Melting Point | 145.0 to 149.0 deg-C |
别名和识别编码
| Chemical Name | Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)- |
|---|---|
| CAS Number | 154229-18-2 |
| Synonym | CB 7630, CB-7630;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate (3?)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester) CB 7630 |
| Chemical Name Translation | 乙酸阿比特龙酯 |
| MDL Number | MFCD00934213 |
| Reaxys-RN | 7314563 |
| PubChem Substance ID | 253661226 |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Steroids,
产品应用
- Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17?-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
相关文献及参考
- [2]. Richards J, et al. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 2012 May 1;72(9):2176-82.
- [3]. Li R, et al. Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer. Clin Cancer Res. 2012 Jul 1;18(13):3571-9.
- [4]. Lee GT, et al. Intracrine androgen biosynthesis in renal cell carcinoma. Br J Cancer. 2017 Mar 28;116(7):937-943.
- [5]. A O'Donnell, et al. Hormonal impact of the 17α-hydroxylase/C17,20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. British Journal of Cancervolume 90, pages2317–2325 (2004)
- Denis, L., et al.: Cancer, 72, 3888 (1993),
- [1]. Stein MN, et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun;
安全信息
- H302 Harmful if swallowed 吞食有害
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
