2-Pyrrolidinone,1-(2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl)-

CAS 148274-76-4 MFCD00915343

化学结构图

148274-76-4
SMILES: OC(CN1CCN(CC1)C1C=CC=CC=1)CN1CCCC1=O

化学属性

Mol. FormulaC17H25N3O2
Mol. Weight303.45

别名和识别编码

Chemical Name2-Pyrrolidinone,1-(2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl)-
Synonym 1-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propyl)-2-pyrrolidinone MG-1 N-(beta-Hydroxy-gamma-(N-phenylpiperazine)propyl)-2-pyrrolidinone
Beilstein Registry Number4328597
CAS Number148274-76-4
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相关文献及参考

  • [1]. Nowaczyk A, et al. QSAR studies on a number of pyrrolidin-2-one antiarrhythmic arylpiperazinyls. Med Chem Res. 2012 Mar;21(3):373-381.

安全信息

RTECSUY5779500
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   44,561,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   44,561,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   44,561,1992

系列性分类


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