Elacridar N-(4-(2-(6,7-二甲氧基-3,4-二氢异喹啉-2(1H)-基)乙基)苯基)-5-甲氧基-9-氧代-9,10-二氢吖啶-4-甲酰胺
CAS 143664-11-3 MFCD00912604
化学结构图
SMILES: COc1cc2c(cc1OC)CN(CCc1ccc(NC(=O)c3cccc4c(=O)c5cccc(OC)c5[nH]c34)cc1)CC2
化学属性
| Mol. Formula | C34H33N3O5 |
|---|---|
| Mol. Weight | 564 |
别名和识别编码
| Chemical Name | Elacridar |
|---|---|
| CAS Number | 143664-11-3 |
| Synonym | Elacridar GF 120918 GF-120918 GF120918 GF120918 GG918 GW0918 N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide GF120918A GG 918 GG918 GW 0918 N-(4-(2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide elacridar n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10h-acridine-4-carboxamide |
| MDL Number | MFCD00912604 |
| Chemical Name Translation | N-(4-(2-(6,7-二甲氧基-3,4-二氢异喹啉-2(1H)-基)乙基)苯基)-5-甲氧基-9-氧代-9,10-二氢吖啶-4-甲酰胺 |
| Reaxys-RN | 7324887 |
| LabNetwork Molecule ID | LN00337963 |
| PubChem Substance ID | 119373 |
| InChI | InChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38) |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- Pharmaceuticals
- {SNA} Bioactive Small Molecule Alphabetical Index, Drug Efflux Pumps, E, Modulators for MDR/TAP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Drug Efflux Pumps, Modulators for MDR/TAP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, New Products
- Intermediates & Fine Chemicals,
- Inhibitors
产品应用
- A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.
相关文献及参考
- Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004),
- Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005),
- Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007),
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
