Sivelestat 西维来司他
CAS 127373-66-4 MFCD00889071
化学结构图
SMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1C=CC=CC=1C(=O)NCC(O)=O
化学属性
| Mol. Formula | C20H22N2O7S · xNa+· yH2O |
|---|---|
| Mol. Weight | 434.46 (anhydrous free acid basis) |
别名和识别编码
| Chemical Name | Sivelestat |
|---|---|
| Synonym | EI 546 sodium salt hydrate Elaspol sodium salt hydrate LY 544349 sodium salt hydrate Ono-5046 sodium salt hydrate o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester) sodium salt hydrate |
| CAS Number | 127373-66-4 (free acid) |
| Chemical Name Translation | 西维来司他 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors, S, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19(2):237-43.
- [3]. Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311(1-2):87-92.
- [4]. Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Aug 28.
- [1]. Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.
- [1]. Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.
- [2]. Yuichiro Toda, et al. A neutrophil elastase i
