CAS 123318-82-1 MFCD00871077-(2R,3R,4S,5R)-5-(6-Amino-2-Chloro-9H-Purin-9-Yl)-4-Fluoro-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol (2R,3R,4S,5R)-5-(6-氨基-2-氯-9H-嘌呤-9-基)-4-氟-2-(羟甲基)四氢呋喃-3-醇 TAO{mole}

(2R,3R,4S,5R)-5-(6-Amino-2-Chloro-9H-Purin-9-Yl)-4-Fluoro-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol (2R,3R,4S,5R)-5-(6-氨基-2-氯-9H-嘌呤-9-基)-4-氟-2-(羟甲基)四氢呋喃-3-醇

CAS 123318-82-1 MFCD00871077

化学结构图

SMILES: NC1=NC(Cl)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F

化学属性

Mol. Formula	C10H11ClFN5O3
Mol. Weight	304
TSCA	No

别名和识别编码

Chemical Name	(2R,3R,4S,5R)-5-(6-Amino-2-Chloro-9H-Purin-9-Yl)-4-Fluoro-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol
CAS Number	123318-82-1
Synonym	(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine 2-Chloro-9-(2-deoxy-2-fluoro-?-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine C1-F-Ara-A Clofarabine
MDL Number	MFCD00871077
Merck Number	2372
PubChem Substance ID	135727330
Chemical Name Translation	(2R,3R,4S,5R)-5-(6-氨基-2-氯-9H-嘌呤-9-基)-4-氟-2-(羟甲基)四氢呋喃-3-醇
Reaxys-RN	4882539

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产品应用

Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.

安全信息

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P301+P310

Hazard statements

H300 Fatal if swallowed 吞食致命

WGK Germany2

Signal word Danger

RTECSUD7473000

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Hazard Codes 6.1 T

Risk Statements

R25 Toxic if swallowed 吞咽有毒

Packing GroupIII

UN Number 2811

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 50 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   51,2386,1991

Storage condition 0-10°C