β-D-Glucopyranuronic acid, 1-[5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate] β-D-Glucopyranuronic acid, 1-[5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate]
CAS 91683-38-4 MFCD00870898
化学结构图
SMILES: CC1C=C(OCCCC(C)(C)C(=O)O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)C(C)=CC=1
化学属性
| Mol. Formula | C21H30O9 |
|---|---|
| Mol. Weight | 426.46 |
别名和识别编码
| Chemical Name | β-D-Glucopyranuronic acid, 1-[5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate] |
|---|---|
| CAS Number | 91683-38-4 |
| Synonym | 1-[5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoate] ?-D-Glucopyranuroic Acid |
| Chemical Name Translation | β-D-Glucopyranuronic acid, 1-[5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate] |
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分类
- Glucuronides
- Inhibitors
- Metabolites & Impurities
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- The major metabolite of Gemfibrozil.
相关文献及参考
- [2]. Baer BR, et al. Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition. Chem Res Toxicol. 2009 Jul;22(7):1298-309.
- [1]. Shitara Y, et al. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2(OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther. 2004 Oct;311(1):228-36.
- [1]. Shitara Y, et al. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2(OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther. 2004 Oct;311(1):228-36.
- [2]. Baer BR, et al. Benzylic oxidation of gemfibrozil-1
安全信息
GHS Symbol
