Misoprostol (free acid)
CAS 112137-89-0 MFCD00869984
化学结构图
SMILES: CCCCC(C)(O)C/C=C/[C@@H]1[C@@H](CCCCCCC(O)=O)C(=O)C[C@H]1O |&1:10,11,24|
化学属性
| Mol. Formula | C21H36O5 |
|---|---|
| Mol. Weight | 369 |
别名和识别编码
| Chemical Name | Misoprostol free acid |
|---|---|
| Synonym | (±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1 |
| MDL Number | MFCD00869984 |
| PubChem Substance ID | 24897131 |
| CAS Number | 112137-89-0 |
| Chemical Name Translation |
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分类
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids, Lipids in Cell Signaling, M, Prostaglandins
- {SNA} Arachidonic Acid Cascade, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids in Cell Signaling, Prostaglandins, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 脂类
- Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
相关文献及参考
- [2]. Schmidt-Hansen M, et al. Simultaneous compared to interval administration of mifepristone and misoprostol for medical abortion up to 10+0 weeks' gestation: a systematic review with meta-analyses. BMJ Sex Reprod Health. 2020 Feb 20. pii: bmjsrh-2019-200448.
- Graham, Y., et al. Lancet 2 , 1277, (1988) 摘要
- [1]. Vijaya Bharathi D, et al. Development and validation of highly sensitive method for determination of misoprostol free acid in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci.
- [1]. Vijaya Bharathi D, et al. Development and validation of highly sensitive method for determination of misoprostol free acid in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 15;879(26):2827-33.
安全信息
GHS Symbol
- P301+P310
- P305+P351+P338
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H301 Toxic if swallowed 吞食有毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H351 Suspected of causing cancer 怀疑致癌
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R60 May impair fertility 可能降低生殖能力
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R25 Toxic if swallowed 吞咽有毒
