CAS 2627-69-2 MFCD00869751-Acadesine AMP-激活的蛋白激酶（AMPK）激动剂类：例如阿卡地新(兴奋剂类，不能销售) TAO{mole}

Acadesine AMP-激活的蛋白激酶（AMPK）激动剂类：例如阿卡地新(兴奋剂类，不能销售)

CAS 2627-69-2 MFCD00869751

化学结构图

SMILES: NC(=O)c1ncn(C2OC(CO)C(O)C2O)c1N

化学属性

Mol. Formula	C9H14N4O5
Mol. Weight	258.23
Melting Point	214-215°C
Density	1.422
Appearance	powder
Solubility	Soluble in water (9 mg/ml), and DMSO (75 mM).
Boiling Point	726.3°C at 760 mmHg

别名和识别编码

Chemical Name	Acadesine
CAS Number	2627-69-2
Synonym	AICAR {LY} AICAR ARA 100 ARA-100 ARA100 Acadesine Acadesine, N1 Acadesine, N1-(-D-Ribofuranosyl)-5-aminoimidazole GP 1 110 Z-riboside acadesine aminoimidazole carboxamide ribonucleoside arasine {} {LY} AICAR {} {} {LY} AICAR {} {} {} {LY} AICAR {} {} {} {} {LY} AICAR {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} AICA riboside {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} AICA ribonucleoside {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem}
PubChem Substance ID	17513
EC Number	220-097-5
MDL Number	MFCD00869751
Beilstein Registry Number	2384789
Chemical Name Translation	AMP-激活的蛋白激酶（AMPK）激动剂类：例如阿卡地新(兴奋剂类，不能销售)
InChI	InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
LabNetwork Molecule ID	LN00194818
Canonical SMILES	OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N)=C(N=C2)C(N)=O)O1

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分类

{SNA} A-AM, AMP-Activated Protein Kinase (AMPK), Bioactive Small Molecules, Cancer Metabolism, Cell Biology, Cell Signaling and Neuroscience, Inhibitors and Activators of the AMPK pathway, Inhibitors of Aerobic Glycolysis (the Warburg Effect), Kinase/Phosphatase Biology, Serine/Threonine Kinase Activators,
{SNA} A-AM, AMP-Activated Protein Kinase (AMPK), AMPK通路抑制剂和激活剂, Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 有氧糖酵解（Warburg效应）, 有氧糖酵解（Warburg效应）抑制剂, 生物活性小分子, 癌症代谢, 癌症研究, 细胞信号转导和神经科学, 细胞生物学

产品应用

An inhibitor of the transcription of PPARα, the coactivation of PPARα.

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xi

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352
P304+P340
P305+P351+P338
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

Acadesine导致ZMP的积累，Acadesine模仿AMP对AMPK和AMPK的刺激作用。
Sigma Aldrich:2627-69-2(sigmaaldrich)
MOL 文件:2627-69-2.mol
color:tan