4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone (2R-顺式)-4-氨基-1-(2-羟甲基-1,3-氧硫杂环戊-5-基)-1H-嘧啶-2-酮

CAS 134678-17-4 MFCD00869739

化学结构图

134678-17-4
SMILES: NC1C=CN([C@@H]2CS[C@H](CO)O2)C(=O)N=1 |&1:5,8|

化学属性

Mol. FormulaC8H11N3O3S
Mol. Weight229
Appearance 21 从甲醇-乙酸乙酯得白色固体。[α] D -132°(C=1.08，甲醇)。或从沸乙醇结晶，熔点160～162℃。[α] -135°(C=0.38，甲醇)。
Melting Point175-179

别名和识别编码

Chemical Name4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Synonym (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine 3TC Epivir Epivir-HBV
MDL NumberMFCD00869739
CAS Number134678-17-4
Reaxys-RN5480511
Merck Number5352
PubChem Substance ID87560180
Chemical Name Translation(2R-顺式)-4-氨基-1-(2-羟甲基-1,3-氧硫杂环戊-5-基)-1H-嘧啶-2-酮
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分类

  • {SNA} AIDS and Viral Research Reagents, Approved Therapeutics/Drug Candidates, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, GlaxoSmithKline, Immune Cell Signaling and Blood, Immune System Regulation, R to Z, Reverse Transcriptase, AMV
  • {Chemicalbook} 药物: 抗病源性微生物药: 抗病毒药物
  • {SNA} AIDS and Viral Research Reagents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, GlaxoSmithKline, Immune Cell Signaling and Blood, Immune System Regulation,

相关文献及参考

  • Butt, Y.M., et al., Highly active antiretroviral therapy does not affect mitochondrial beta-oxidation of fatty acids: an in vitro study in fibroblasts. Pediatr. Dev. Pathol. 11 , 35-38, (2008)
  • Perez-Olmeda, M., et al., In vitro analysis of synergism and antagonism of different nucleoside/nucleotide analogue combinations on the inhibition of human immunodeficiency virus type 1 replication. J. Med. Virol. 81 , 211-216, (2009) 摘要
  • Kohler, J.J., et al., Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation. Lab. Invest. 89 , 122-130, (2009)
  • Merck 14 ,5352

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P305+P351+P338
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Hazard Codes Xi
RTECSUW7361333
Storage condition <;0 <0°C
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Immune System Regulation - Immune Cell Signaling and Blood
  6. AIDS and Viral Research Reagents - Immune System Regulation
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. R to Z - Enzyme Inhibitors by Enzyme
  7. Reverse Transcriptase, AMV - R to Z
  1. Functional Group 官能团索引
  2. thioacetal

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