4-Methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione 4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮
CAS 64224-21-1 MFCD00868499
化学结构图
SMILES: CC1C(=S)SSC=1C1=CN=CC=N1
化学属性
| Mol. Formula | C8H6N2S3 |
|---|---|
| Mol. Weight | 226.34 |
| TSCA | No |
别名和识别编码
| Chemical Name | 4-Methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione |
|---|---|
| Synonym | RP-35,972 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione Oltipraz 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione BRN 0978110 CCRIS 4048 NSC 347901 RP 35972 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione |
| MDL Number | MFCD00868499 |
| EC Number | 264-736-6 |
| CAS Number | 64224-21-1 |
| Wiswesser Line Notation | T6N DNJ B- ET5SSYJ CUS D1 |
| Beilstein Registry Number | 0978110 |
| Chemical Name Translation | 4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, O, 生物活性小分子, 细胞生物学
- {SNA} Bioactive Small Molecules, Cell Biology, O
相关文献及参考
- [2]. Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234(2):73-87.
- [3]. Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5.
- [4]. Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49(2):324-33.
- [1]. Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effec
- [1]. Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S37 Wear suitable gloves 戴适当手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 37XLA2 "Current Chemotherapy, Proceedings of the 10th International Congress of Chemotherapy, Zurich, 1977," Siegenthaler, W., and R. Luethy, eds., 2 vols., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,148,1978
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,359,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 43 mg/kg/D TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,359,1980
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,359,1980
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 1 mg/L REFERENCE : CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,379,1986
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 1 mg/L REFERENCE : CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,379,1986
