CAS 29975-16-4 MFCD00867537-4H-s-Triazolo(4,3-a)(1,4)benzodiazepine,8-chloro-6-phenyl- TAO{mole}

4H-s-Triazolo(4,3-a)(1,4)benzodiazepine,8-chloro-6-phenyl-

CAS 29975-16-4 MFCD00867537

化学结构图

SMILES: ClC1=CC2C(=NCC3=NN=CN3C=2C=C1)C1C=CC=CC=1

化学属性

Mol. Formula	C16H11ClN4
Mol. Weight	294.76

别名和识别编码

Chemical Name	4H-s-Triazolo(4,3-a)(1,4)benzodiazepine,8-chloro-6-phenyl-
CAS Number	29975-16-4
Synonym	Julodin NSC 290818 Cannoc U 33737 Eurodin D-40TA 4H-(1,2,4)Triazolo(4,3-a)(1,4)-benzodiazepine, 8-chloro-6-phenyl- Nuctalon Nemurel Abbott 47631 ProSom Estazolam Esilgan D 40TA 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine Somnatrol Prosom
MDL Number	MFCD00867537
PubChem Substance ID	24894524
EC Number	249-982-4
Wiswesser Line Notation	T B576 BN DNN HN GHJ IR& LG
Beilstein Registry Number	1220868

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分类

Abbott, Alphabetic, Analytical Standards, Analytical/Chromatography, Approved Therapeutics/Drug Candidates, Benzodiazepin Analoga Structure, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, E, EQ - EZ, Forensic and Veterinary Standards, Neat Compounds, Neurobiology, Neuroscience, Pharmacologicals
{SA} Abbott, Alphabetic, Analytical Standards, Analytical/Chromatography,
{SNA} Abbott,

产品应用

A benzodiazepine derivative possessing anxiolytic, anticonvulsant, and muscle relaxant properties. It is commonly prescribed to treat short-term insomnia.

安全信息

RTECSXZ5473500

WGK Germany3

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Hazard Codes Xi

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Signal word Warning

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 6,530,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,103,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 339 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 6,530,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 32,152,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15 gm/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 32,158,1973