Ethamsylate 酚磺乙胺

CAS 2624-44-4 MFCD00867499

化学结构图

2624-44-4
SMILES: CCNCC.O=S(=O)(O)c1cc(O)ccc1O

化学属性

Mol. FormulaC10H17NO5S
Mol. Weight263
Appearance 白色结晶性粉末。熔点125℃（127-131℃）。易溶于水，溶于乙醇，微溶于丙酮，不溶于氯仿、乙醚。有引湿性，遇光易变质。无臭，味苦。
SolubilityDMSO 53 mg/mL Water 53 mg/mL Ethanol <1 mg/mL
Melting Point128.0 to 132.0 deg-C

别名和识别编码

Chemical NameEthamsylate
CAS Number2624-44-4
Alfabeta NameDIHYDROXYBENZENESULFONICACIDNETHYLETHANAMINE :2511()--,
MDL NumberMFCD00867499
Synonym ######## 1-Hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic acid compd. with 1-hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonicacidcompd.withdiethylamine 2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine 2,5-Dihydroxybenzenesulfonic acid compd. with N-ethylethanamine 2,5-DihydroxybenzenesulfonicacidcompdwithN-ethylethanamine 2,5-dihydroxy-benzenesulfonicacicompd.withdiethylamine 2,5-dihydroxy-benzenesulfonicacicompd.withn-ethylethanamine(1:1) 2,5-dihydroxybenzenesulfonicacidcompd.withn-ethylethanamine 2,5-二羟基苯磺酸二乙胺盐 Aglumin Altodor Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1) Ciclonamina Cyclonamine Dicinone Dicynene Dicynone Diethylammonium 2,5-dihydroxybenzenesulfonate Diethylammonium cyclohexad
EC Number220-090-7
Chemical Name Translation酚磺乙胺
Reaxys-RN4166074
Merck Number3722
PubChem Substance ID17506
Wiswesser Line NotationWSQR BQ EQ &2M2
LabNetwork Molecule IDLN00160636
InChIInChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Hemostatic.

相关文献及参考

  • Estrada, E., et al.: Bioorg. Med. Chem., 8, 2755 (2000),
  • Du, X., et al.: J. Med. Chem., 45, 2695 (2002),

安全信息

Warnings IRRITANT
Storage condition 储存温度 2-8°C 储存温度-20°C
RTECSDB6145000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,180,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6040 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,180,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29750 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Behavioral - excitement
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (5),40,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 15,110,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympa

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,159,1974

Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P337+P313
  • P337+P317

其他信息

  • 方法一:由二乙胺用二氧化硫成盐后与对苯二醌加成而得。将二乙胺、乙醇和水加入反应锅内，冷至0℃，通入二氧化硫至反应液pH=3.5-4为止，反应温度控制在10℃以下，得二乙胺亚硫酸盐溶液。然后，于0-10℃缓缓加入对苯二醌。加毕，减压回收乙醇，冷却结晶，过滤。结晶加蒸馏水加热溶解，用活性炭脱色精制，即得酚磺乙胺成品。
  • MSDS 信息:Etamsylate(2624-44-4).msds
  • MOL 文件:2624-44-4.mol
  • 上游原料:二乙胺 --> 二氧化硫 --> 苯醌 --> 二乙氨基乙醇
  • 用途一:用于手术前预防和治疗出血，也用于肠道出血、脑出血和泌尿道出血等
  • 用途二:本品能增加血小板的数量、聚集性和粘附性，促使凝血活性物质从血小板中释放。也可加速血块收缩，缩短凝血时间，还可以增强毛细血管抵抗力，减低毛细血管通透性。用于手术前预防和治疗出血。也用于血小板功能不全引起出血或其他原因出血，如胃肠道出血、脑出血和泌尿道出血等。鼠静脉注射LD50为800-1350毫克/公斤。
  • Ethamsylate是一种止血药，抑制前列腺素的生物合成和功能，提高毛细血管内皮阻力和血小板粘附。

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Prostaglandin Receptor  (前列腺素受体)

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