Zardaverine
CAS 101975-10-4 MFCD00867059
化学结构图
SMILES: COC1=CC(=CC=C1OC(F)F)C1C=CC(=O)NN=1
化学属性
| Mol. Formula | C12H10F2N2O3 |
|---|---|
| Mol. Weight | 268.22 |
别名和识别编码
| Chemical Name | Zardaverine |
|---|---|
| Synonym | 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone Zardaverine |
| MDL Number | MFCD00867059 |
| PubChem Substance ID | 24278784 |
| CAS Number | 101975-10-4 |
| Chemical Name Translation |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, G Proteins and Cyclic Nucleotides, P to Q, Phosphodiesterase III and IV, Phosphodiesterase Inhibitors, Z
- {SNA} Cyclic Nucleotide Metabolism, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G Proteins and Cyclic Nucleotides, P to Q, Phosphodiesterase III and IV, Phosphodiesterase Inhibitors, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
相关文献及参考
- [2]. D. Ukena, K. Rentz, C. Reiber, et al. Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction. Respiratory Medicine.1995, 89 ( 6) : 441-444.
- [3]. Schade FU, Schudt C. The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages. European Journal of Pharmacology.1993, 230(1):9-14.
- 1. Schudt, C., et al., Zardaverine as a selective inhibitor of phosphodiesterase isozymes Biochem. Pharmacol. 42 , 153-162, (1991)
- Underwood, D.C., et al. J. Pharmacol. Exp. Ther. 270 , 250, (1994) 摘要
- [1]. R.T. Schermuly, H. Leuchte, H.A. Ghofrani, et al. Zardaverine and aerosolised iloprost in a model of acute respiratoryfailure. ERJ, 2003 ,22 (2): 34
- [1]. R.T. Schermuly, H. Leuchte, H.A. Ghofrani, et al. Zardaverine and aerosolised iloprost in a model of acute respiratoryfailure. ERJ, 2003 ,22 (2): 342-347.
