2'-F-5-I-dU 5-碘-2'-氟脱氧尿苷
CAS 69123-98-4 MFCD00866922
化学结构图
SMILES: O[C@@H]1[C@@H](F)[C@H](O[C@H]1CO)N1C=C(I)C(=O)NC1=O |&1:1,2,4,6|
化学属性
| Mol. Formula | C9H10FIN2O5 |
|---|---|
| Mol. Weight | 372 |
| Melting Point | 226 |
别名和识别编码
| Chemical Name | 2'-F-5-I-dU |
|---|---|
| CAS Number | 69123-98-4 |
| Synonym | 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-Pyrimidinedione 2'-Fluoro-5-iodoarauracil 2,4(1H,3H)-Pyrimidinedione, FIAU |
| Beilstein Registry Number | 892318 |
| Chemical Name Translation | 5-碘-2'-氟脱氧尿苷 |
| Wiswesser Line Notation | T6NVMVJ EI A- BT5OTJ CF DQ E1Q |
| MDL Number | MFCD00866922 |
| PubChem Substance ID | 160871154 |
| LabNetwork Molecule ID | LN01315972 |
| Reaxys-RN | 892318 |
| Merck Number | 4069 |
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分类
- Bases & Related Reagents
- Nucleotides
- Anti-virals
- {SNA} AIDS and Viral Research Reagents, Bioactive Small Molecule Alphabetical Index, F, Immune Cell Signaling and Blood, Immune System Regulation, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Intermediates & Fine Chemicals,
- Pharmaceuticals
产品应用
- An antiviral agent; nucleoside analog with antihepatitis B activity.
相关文献及参考
- Watanabe A., et al.: J. Med. Chem., 22, 21 (1979),
- Colacino, J.M., et al.: Antimicrob. Agents Chemother., 24, 505 (1983),
- Staschke, K.A., et al.: Antiviral Res., 23, 45 (1994),
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 9100 ug/kg/13W-I TOXIC EFFECTS : Liver - jaundice, other or unclassified Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic acidosis REFERENCE : NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 333,1099,1995
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 40 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,3957,1982
