Nimustine
CAS 42471-28-3 MFCD00866532
化学结构图
SMILES: CC1N=CC(CNC(=O)N(CCCl)N=O)=C(N)N=1
化学属性
| Mol. Formula | C9H13ClN6O2 |
|---|---|
| Mol. Weight | 272.73 |
别名和识别编码
| Chemical Name | Nimustine |
|---|---|
| Synonym | 3-(4-Amino-2-methyl-5-pyrimidinyl)methyl-1-(2-chloroethyl)-1-nitrosourea Nimustine |
| CAS Number | 42471-28-3 |
| Beilstein Registry Number | 0685903 |
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安全信息
TYPE OF TEST : DNA damage TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 50 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,1361,1987
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 8 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 75 ug/plate REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal o
TYPE OF TEST : Mutation in microorga
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 2 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,95,1985
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 8 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,1361,1987
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 2 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,95,1985
TYPE OF TEST
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE : 3 mg/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : YSKODB Yakubutsu, Seishin, Kodo. Japanese Journal of Psychopharmacology. (Nippon Shinkei, Seishin Yakuri Gakkai, 1433 Nogawa, Miyamae-ku, Kawasaki, 213, Japan) V.1- 1981- Volume(issue)/page/year: 11,438,1991
