(S)-2-(N-((2’-(1H-Tetrazol-5-yl)-[1,1’-Biphenyl]-4-yl)Methyl)Pentanamido)-3-Methylbutanoic Acid (S)-2-(N-(((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)戊酰胺基)-3-甲基丁酸
CAS 137862-53-4 MFCD00865840
化学结构图
SMILES: [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(=O)N(CC1=CC=C(C=C1)C1=CC=CC=C1C1NN=NN=1)[C@@H](C(C)C)C(O)=O
化学属性
| Mol. Formula | C24H29N5O3 |
|---|---|
| Mol. Weight | 435.53 |
| Melting Point | 116-117 |
别名和识别编码
| Chemical Name | (S)-2-(N-((2’-(1H-Tetrazol-5-yl)-[1,1’-Biphenyl]-4-yl)Methyl)Pentanamido)-3-Methylbutanoic Acid |
|---|---|
| CAS Number | 137862-53-4 |
| Alfabeta Name | TETRAZOLYLBIPHENYLYLMETHYLPENTANAMIDOMETHYLBUTANOICACID SNH22151143[]((((()))))-------------,'' |
| MDL Number | MFCD00865840 |
| Synonym | N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine |
| Chemical Name Translation | (S)-2-(N-(((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)戊酰胺基)-3-甲基丁酸 |
| PubChem Substance ID | 125307697 |
| Reaxys-RN | 7754038 |
| Merck Number | 9916 |
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分类
- {SNA} Angiotensin Receptor Antagonists, Angiotensins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Novartis, Peptides and Proteins, Peptides for Cell Biology, V, 生化试
相关文献及参考
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- [3]. Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19(8):1773-82.
- [4]. Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9.
- [5]. Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12.
- [1]. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
