5-(4-((1-Methylcyclohexyl)Methoxy)Benzyl)Thiazolidine-2,4-Dione 环格列酮
CAS 74772-77-3 MFCD00865499
化学结构图
SMILES: CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1
化学属性
| Mol. Formula | C18H23NO3S |
|---|---|
| Mol. Weight | 333 |
别名和识别编码
| Chemical Name | 5-(4-((1-Methylcyclohexyl)Methoxy)Benzyl)Thiazolidine-2,4-Dione |
|---|---|
| CAS Number | 74772-77-3 |
| Synonym | (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione Ciglitazone (+/-)-5-[4-(1-methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione ADD 3878 ADD-3878 Ciglitazone Ciglitizone U 63287 |
| MDL Number | MFCD00865499 |
| PubChem Substance ID | 24892661 |
| Chemical Name Translation | 环格列酮 |
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分类
- Sulfur & Selenium Compounds
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, CI-CZ, Gene Regulation, Gene Regulation and Expression, PPAR and RXR Regulators, Takeda, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Antitumor Agents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, CI-CY, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression, PPAR and RXR Regulators, Takeda
产品应用
- Displays antihyperglycemic activity in genetically obese mice. It is a selective PPARg agonist.
相关文献及参考
- Clark, D.A., et al.: J. Med. Chem., 34, 319-325 (1991); Sohda, T., et al.: Chem. Pharm. Bull., 30(10), 3580-3600, (1982)
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 950 mg/kg SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 26,169,1986
