Morpholine,4-((4-(2-chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4) diazepin-2-yl)-1-oxopropyl)-
CAS 105219-56-5 MFCD00865271
化学结构图
SMILES: CC1=NN=C2CN=C(C3C=C(CCC(=O)N4CCOCC4)SC=3N21)C1=CC=CC=C1Cl
化学属性
| Mol. Formula | C22H22ClN5O2S |
|---|---|
| Mol. Weight | 455.96 |
别名和识别编码
| Chemical Name | WEB2086 |
|---|---|
| CAS Number | 105219-56-5 |
| Synonym | 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone Apafant WEB 2086BS 4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]morpholine Apafant WEB 2086 WEB 2086BS WEB2086 |
| MDL Number | MFCD00865271 |
| Wiswesser Line Notation | T B575 AN CS HN KNN GHJ D2V- AT6N DOTJ& GR BG M1 |
| Beilstein Registry Number | 4302553 |
| PubChem Substance ID | 329825250 |
| Chemical Name Translation |
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分类
- Pharmaceuticals
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, New Products, Platelet Activating Factors
- {SNA} Bioactive Small Molecule Alphabetical Index, Lipids in Cell Signaling, Platelet Activating Factors, W, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds,
产品应用
- Platelet activating factor (PAF) antagonist.
相关文献及参考
- Casals-Stenzel, J., et al.: J. Pharmacol. Exp. Ther., 241, 974 (1987),
- Adamus, W.S., et al.: Clin. Pharmacol. Ther., 47, 456 (1990),
- Brecht, H.M., et al.: Arzneim.-Forsch., 41, 51 (1991),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4968794
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4968794
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 36 gm/kg
SEX/DURATION : female 6-12 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 52,215,1996TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 3250 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Fertility - abortion Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 52,209,1996
