Clarithromycin 克拉霉素
CAS 81103-11-9 MFCD00865140
化学结构图
SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)OC
化学属性
| Mol. Formula | C38H69NO13 |
|---|---|
| Mol. Weight | 747.96 |
| Melting Point | 217-220 |
| Boiling Point | 86 |
别名和识别编码
| Chemical Name | Clarithromycin |
|---|---|
| MDL Number | MFCD00865140 |
| CAS Number | 81103-11-9 |
| Reaxys-RN | 3581974 |
| PubChem Substance ID | 87560041 |
| Merck Number | 2339 |
| Synonym | Clathromycin |
| Chemical Name Translation | 克拉霉素 |
| InChIKey | AGOYDEPGAOXOCK-KCBOHYOISA-N |
| LabNetwork Molecule ID | LN00840492 |
| Beilstein Registry Number | 3581974 |
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分类
- 1694 Pharmaceuticals & Personal Care Products, A - K, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, EPA, Macrolides, Method Specific, Neats, Spectrum of Activity
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
相关文献及参考
- [2]. Niemi, M., P.J. Neuvonen, and K.T. Kivisto, The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide. Clin Pharmacol Ther, 2001. 70(1): p. 58-65.
- 1. Masahito Ogawa, Jun-ichi Suzuki, et al., Clarithromycin Attenuates Acute and Chronic Rejection Via Matrix Metalloproteinase Suppression in Murine Cardiac Transplantation J. Am. Coll. Cardiol. 51 , 1977-1985, (2008) 摘要
- 2. Ilknur Basyigit, Fusun Yildiz, et al., The Effect of Clarithromycin on Inflammatory Markers in Chronic Obstructive Pulmonary Disease: Preliminary Data Ann. Pharmacother. 38 , 1400-1405, (2004) 摘要
- 3. Hardy, D.J. et al. Diagn. Microbiol. Infect. Dis. 15 , 39-53, (1992)
- 4. Langtry, H.D., and Brogden, R.N. Drugs 53 , 973-1004, (1997) 摘要
- 5. Hardy, D.J, et al. Antimicrob. Agents Chemother. 32 , 1710-1719, (1988)
- Merck 14 ,2339
- [1]. http://en.wi
- [1]. http://en.wikipedia.org/wiki/Clarithromycin
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P312+P330
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 173 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,769,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1270 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 22,1433,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBS
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 30 mg/kg/3D-I TOXIC EFFECTS : Cardiac - pulse rate increase, without fall in BP Cardiac - change in rate REFERENCE : AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 30,542,1997
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Skin and Appendages - corrosive (after topical exposure) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
