1, 2α- 亚甲基- 6- 氯- 17α- 乙酰氧基- 4, 6- 孕二烯- 3, 20- 二酮 1, 2α- 亚甲基- 6- 氯- 17α- 乙酰氧基- 4, 6- 孕二烯- 3, 20- 二酮
CAS 427-51-0 MFCD00864671
化学结构图
SMILES: CC(=O)OC1(C(C)=O)CCC2C3C=C(Cl)C4=CC(=O)C5CC5C4(C)C3CCC21C
化学属性
| Mol. Formula | C24H29ClO4 |
|---|---|
| Mol. Weight | 417 |
| Melting Point | 206.0-211.0 |
别名和识别编码
| Chemical Name | 1, 2α- 亚甲基- 6- 氯- 17α- 乙酰氧基- 4, 6- 孕二烯- 3, 20- 二酮 |
|---|---|
| Synonym | 17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat 6-Chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione 6-Chloro-1β,2β-dihydro-17-hydroxy-3'H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate 6-Chloro-1β,2β-dihydro-17-hydroxy-3′H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate Androcur Cyproterone Acetate Cyproterone Acetate, (1 alpha,2 alpha)-Isomer Cyproterone Acetate, (1 alpha,2 alpha,9 beta,10 alpha)-Isomer Cyproterone Acetate, (17 alpha)-Isomer Cyproterone acetate |
| MDL Number | MFCD00864671 |
| PubChem Substance ID | 253660432 |
| CAS Number | 427-51-0 |
| EC Number | 207-048-3 |
| Chemical Name Translation | 1, 2α- 亚甲基- 6- 氯- 17α- 乙酰氧基- 4, 6- 孕二烯- 3, 20- 二酮 |
| InChIKey | UWFYSQMTEOIJJG-FDTZYFLXSA-N |
| Wiswesser Line Notation | L F3 E6 D665 IV JU LUTJ A1 E1 RV1 RQ |
| Beilstein Registry Number | 2342172 |
| LabNetwork Molecule ID | LN01279769 |
| Reaxys-RN | 2342172 |
| Merck Number | 2774 |
| InChI | InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1 |
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分类
- Androgen Modulators, Antitumor Agents, Bioactive Small Molecules, CI-CY, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
- {
- {SNA} Androgen Modulators, Antitumor Agents, Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience,
- {SNA} Androgen Modulators, Antitumor Agents, Bioactive Small Molecules, CI-CY, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Gene Regulation,
- {SNA} Androgen Modulators, Antitumor Agents, Cytokines, Growth Factors and Hormones, Gene Regulation,
相关文献及参考
- 1. Tucker et al. Carcinogenesis 17 , 1473-1476, (1996) 摘要
- 2. Kasper, P., Cyproterone acetate: a genotoxic carcinogen? Pharmacol. Toxicol. 88 , 223-231, (2001) 摘要
- Kasper, P., and Mueller, L. Carcinogenesis 20 , 2185, (1999) 摘要
- Mondal, S., and Rai, U. Gen. Comp. Endocrinol. 116 , 291, (1999) 摘要
- Hofbauer, R. Fertil. Steril. 72 , 652, (1999) 摘要
- Benjamin, C.L., et al., Use of artificial androgen receptor coactivators to alter myoblast proliferation. J. Steroid Biochem. Mol. Biol. 91 , 111-9, (2004) 摘要
- Sanseverino, J., et al., Screening of Potentially Hormonally Active Chemicals Using Bioluminescent Yeast Bioreporters Toxicol. Sci. 107 , 122-34, (2009) 摘要
- Dey, C.J., et al., Behavioral and physiological responses of a wild teleost fish to cortisol and androgen manipulation during parental care. Horm. Behav. , (2010)
- Merck 14 ,2774
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P302+P352
- P304+P312
- P304+P340
- P308+P313
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H312 Harmful in contact with skin 皮肤接触有害
- H312+H332
- H332 Harmful if inhaled 吸入有害
- H351 Suspected of causing cancer 怀疑致癌
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- S22 Do not breathe dust 不要吸入粉尘；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27 gm/kg/78W TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,688,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 70 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 17,1473,1996
TYPE OF TEST : LD50 - Let
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-4,1982
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 171 mg/kg/17W-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Liver - jaundice (or hyperbilirubinemia) hepatocellular Liver - liver function tests impaired REFERENCE : IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965- Volume(issue)/page/year: 30,238,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 565 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-4,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE
TYPE OF TEST : Morphological transformation ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 125 mg/kg/5D (Continuous) REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 14,1229,1993
TYPE OF TEST : DNA damage TEST SYSTEM : Human Liver DOSE/DURATION : 50 umol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 16,1265,1995
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Liver DOSE/DURATION : 1 umol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 16,1265,1995
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 100 mg/kg REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/
TYPE OF TEST : DNA repair TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 5 umol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 16,1483,1995
TYPE OF TEST : DNA damage ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 1 mg/kg REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 35 mg/kg SEX/DURATION : male 7 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 49,237,1977
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 150 mg/kg SEX/DURATION : female 17-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : PTRBAE Philosophical Transactio
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE : 1 mg/kg SEX/DURATION : male 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Vo
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 180 mg/kg SEX/DURATION : female 18 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73, 90141 Palermo, Italy) V.1- 1969- Volume(issue)/page/year: 10,57,1979
