Methyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate 5-丁基-2-苯并咪唑氨基甲酸甲酯

CAS 14255-87-9 MFCD00864534

化学结构图

14255-87-9
SMILES: CCCCC1=CC2N=C(NC=2C=C1)NC(=O)OC

化学属性

Mol. FormulaC13H17N3O2
Mol. Weight247
Melting Point255-257 ºC
Solubility<0.1 G/100 ML AT 18 ºC

别名和识别编码

Chemical NameMethyl (5-butyl-1H-benzo[d]imidazol-2-yl)carbamate
EC Number238-133-3
Synonym Worm Guard SKF 29044 (4-Butyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester 5-Butyl-2-benzimidazolecarbamic acid methyl ester; 5-Butyl-2-(carbomethoxyamino)benzimidazole Parbendazole N-(Butyl-5, benzimidazolyl)-2, carbamate de methyle Verminum Methyl 5-butyl-2-benzimidazolecarbamate Carbamic acid, (5-butyl-1H-benzimidazol-2-yl)-, methyl ester Helmatac PBDZ 5-Butyl-2-benzimidazolecarbamic acid methyl ester 5-Butyl-2-(carbomethoxyamino)benzimidazole
CAS Number14255-87-9
Wiswesser Line NotationT56 BM DNJ CMVO1 G4
Chemical Name Translation5-丁基-2-苯并咪唑氨基甲酸甲酯
MDL Number
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相关文献及参考

  • [2]. Havercroft JC, et al. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204.
  • [3]. Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. Eur J Biochem. 1987 Mar 16;163(3):449-55.
  • [1]. Lo YC, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7(1):11261.
  • [1]. Lo YC, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7(1):11261.
  • [2]. Havercroft JC, et al. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204.
  • [3]. Foster KE, et a

安全信息

RTECSDD6495000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3657267

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   AUVJA2 Australian Veterinary Journal.  (Australian Veterinary Assoc.,
   Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 
     1927-  Volume(issue)/page/year: 46,297,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
   Comparee de Lyon.  (Lyons, France)  V.1-83, 1898-1981.
   Volume(issue)/page/year: 77,379,1975

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - cattle
DOSE/DURATION           : >1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AUVJA2 Australian Veterinary Journal.  (Australian Veterinary Assoc.,
   Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 
     1927-  Volume(issue)/page/year: 46,297,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
D

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - domestic Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 2,67,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 30 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   COVEAZ Cornell Veterinarian.  (Cornell Univ. New York State College of
   Veterinary Medicine, Ithaca, NY 14853)  V.1-    1911-
   Volume(issue)/page/year: 64(Suppl 4),56,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   RMVEAG Recueil de Medecine Veterinaire.  (Masson Pub. USA, Inc., Year Book
   Medical Pub., 35 E. Wacker Dr., Chicago IL 60601)  V.1-    1824-
   Volume(issue)/page/year: 152,467,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 31,505,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal dea

系列性分类

  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule/Tubulin  (微管/微管蛋白)

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